Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.

Pain Res Manag · 2017 · PMC5438848 · PMID 28555092

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fell just short of statistical significanceno p-value reported

Even with this smaller patient cohort, in a group of heavily pretreated patients and with advanced disease, the pain coprimary endpoint fell just short of statistical significance, with a clinically meaningful NNT between 4 and 6.

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