A study using a similar immunoprecipitation technique that also targeted L1CAM showed a highly significant increase in alpha-synuclein in L1CAM+ EVs in Parkinson's disease (PD) patients compared to controls, which also correlated with disease severity (Shi et al., 2014 ).
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Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.
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