TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells.

Using PWMs for both TCF21 and AHR, we found highly significant enrichment for co-localization in regions of open chromatin in HCASMC, and characterized similar organization of these binding sites around transcription factor start sites, suggesting functional interaction between TCF21 and AHR and the basal transcriptional apparatus, as proposed previously for other TFs.[ 48 , 49 ] The genomic co-localization was further refined by intersecting summit locations from TCF21 ChIP-seq data with AHR-ARNT PWM positions.

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