Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate.

Elife · 2017 · PMC5440169 · PMID 28362259

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp=6.1 × 10 −9actually significant

Interestingly, in the top-ten ranking splice sites, we see a highly significant enrichment of splice sites associated to COSMIC genes (p=6.1 × 10 −9 , Fisher’s exact test).

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marginally significantp=6.5 × 10 −2so close (0.05 < p ≤ 0.1)

We further observe a marginally significant decrease in survival associated with STK11 splice site mutations for LUAD TCGA exome samples (p=6.5 × 10 −2 , Log-rank test) ( Figure 7E ).

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