Prostaglandin E<sub>2</sub> inhibits matrix mineralization by human bone marrow stromal cell-derived osteoblasts via Epac-dependent cAMP signaling.

Sci Rep · 2017 · PMC5440379 · PMID 28533546

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highly significantno p-value reported

However, the inhibitory effects of PGE 2 were not diminished, and reductions in Alizarin Red S staining remained highly significant even when dexamethasone was completely absent (Fig. 5B ).

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