Modulation of Aneuploidy in <i>Leishmania donovani</i> during Adaptation to Different <i>In Vitro</i> and <i>In Vivo</i> Environments and Its Impact on Gene Expression.

In contrast, the S values of two chromosomes increased from promastigotes to amastigotes, as follows: (i) chromosome 8, from 2.15 ± 0.4 to 3.07 ± 0.12 in P3 and 2.95 ± 0.16 in P4 (both differences significant), and (ii) chromosome 10, from 1.74 ± 0.37 to 2.30 ± 0.10 in P3 (not significant) and 2.47 ± 0.14 in P4 (marginally significant) ( Fig. 2C ; Data Set S1A1 ). 10.1128/mBio.00599-17.1 DATA SET S1 (A) Statistical significance of changes in S values for samples whose results are shown in Fig. 2 and 3 (A1) and for all the samples (A2).

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