The spleen in liver cirrhosis: revisiting an old enemy with novel targets.

J Transl Med · 2017 · PMC5442653 · PMID 28535799

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highly significantno p-value reported

Overall, the identification of portal hypertension-induced mTOR signaling alterations may be highly significant due to its central roles in immune cell modulation, angiogenesis and hepatic fibrogenesis [ 26 – 28 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.