Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes.

Intensive Care Med Exp · 2017 · PMC5446430 · PMID 28550659

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a decreasing trendno p-value reported

In mice ventilated for 12 h, a significant increase in TNF-α, IFN-γ, IL-1β, IL-10, and MCP-1 ( P < 0.01) was observed with 90% FiO 2 , whereas IL-6 showed a decreasing trend ( P for trend = 0.03) across FiO 2 groups.

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