Prevalence and Incidence Trends for Diagnosed Prescription Opioid Use Disorders in the United Kingdom.

Pain Ther · 2017 · PMC5447547 · PMID 28451867

Europe PMC DOI

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an increasing trendno p-value reported

A study using UK death data from the Office for National Statistics has shown an increasing trend in the number of deaths attributable to opioids from 2001 to 2011 [ 15 ].

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a decreasing trendno p-value reported

In analyses stratified by opioid drug, we found that the relation between opioid use disorders and prescriptions of codeine and tramadol remained stable, whereas there was an increasing trend for morphine and a decreasing trend related to dihydrocodeine.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.