Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.

J Pain Res · 2017 · PMC5449157 · PMID 28579821

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considerably significantlyno p-value reported

Coadministration of rifampin considerably significantly reduced the mean AUC and C max of morphine by 27.7% and 40.7%, respectively, and consequently abolished the analgesic effect of morphine.

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