ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing.

Nucleic Acids Res · 2017 · PMC5449610 · PMID 28334849

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highly significantno p-value reported

Despite cell culturing, B-LCLs maintain highly significant ICF-specific differences in mRNA levels of immunoglobulin genes [( 31 , 32 ) and the present study] and high frequencies of karyotype anomalies described in mitogen-stimulated ICF lymphocytes ( 27 ).

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