The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical.

Arthritis Res Ther · 2017 · PMC5452396 · PMID 28569212

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a nonsignificant trendno p-value reported

In addition, some studies showed lower frequencies of autoantibodies in RA patients presenting at older age [ 9 – 14 ], while other studies observed no differences [ 15 , 16 ] or showed a nonsignificant trend toward a higher prevalence of ACPA in RA patients presenting at older age [ 17 , 18 ].

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