highly significantP<0.001
As predicted, a highly significant association was detected between tumor size (HR, 1.933; 95% CI, 1.429–2.613; P<0.001), TNM stage (HR, 2.843; 95% CI, 2.088–3.871; P<0.001), TopoIIα (HR, 2.320; 95% CI, 1.708–3.151; P<0.001), Ki67 (HR, 1.760; 95% CI, 1.297–2.389; P<0.001) and the development of tumor recurrence by the univariate analysis method.