A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells.

It can be noted that DNMT3A and DNMT3B mRNA expression is down-regulated in an extremely significant manner in both cell lines ( Figure 4 C–F).

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The combination treatment of SFN and WA in MCF-7 cells is more effective in the inhibition of DNMT activity than singly administered SFN but not WA, and in MDA-MB-231 cells the combination treatment effect was highly significant, more so than with the singly administered WA.

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