The microbial changes in subgingival plaques of orthodontic patients: a systematic review and meta-analysis of clinical trials.

BMC Oral Health · 2017 · PMC5455174 · PMID 28576147

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a decreasing trendno p-value reported

However, another study reported an increasing trend in the frequency of Pi after three months and a decreasing trend after six months.

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an increasing trendno p-value reported

The three remaining studies [ 7 , 16 , 22 ] found an increasing trend in Tf following appliance placement but without a significant difference.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.