Suboptimal Dosing Parameters as Possible Factors in the Negative Phase III Clinical Trials of Progesterone for Traumatic Brain Injury.

J Neurotrauma · 2017 · PMC5455214 · PMID 26370183

Europe PMC DOI

hedged sentence

0.0480

closest p · 1.0× alpha

0.0480

boldest claim

The sentences

borderline significancep = 0.048actually significant

While it has been noted that the positive GOS effect at 6 months had dropped to only borderline significance ( p = 0.048), 5 there were 159 patients, lending credence to a functional efficacy signal in these severely-injured patients with this much lower dose and slightly longer schedule (2 mg/kg/day × 5 days).

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