Trastuzumab Emtansine With or Without Pertuzumab Versus Trastuzumab Plus Taxane for Human Epidermal Growth Factor Receptor 2-Positive, Advanced Breast Cancer: Primary Results From the Phase III MARIANNE Study.

PFS was descriptively analyzed in prespecified subgroups and findings were generally consistent with the main analysis conducted in the intention-to-treat population ( Fig 2B ); however, there was a numerical trend that favored treatment with T-DM1 for patients who had received previous neoadjuvant or adjuvant therapy with trastuzumab or lapatinib (prior treatment: HR, 0.75 [97.5% CI, 0.52 to 1.09]; no prior treatment: HR, 1.12 [97.5% CI, 0.82 to 1.54]) and for patients who had received prior taxane (prior taxane: HR, 0.69 [97.5% CI, 0.48 to 0.99]; no prior taxane: HR, 1.10 [97.5% CI, 0.85 to 1.41]).

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