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Adverse drug events-Analysis of a decade. A Portuguese case-study, from 2004 to 2013 using hospital database.

PLoS One · 2017 · PMC5456097 · PMID 28575013

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an increasing trendno p-value reported
Conclusion In the last decade an increasing trend of ADR were observed and an AP pattern relatively stable.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.