highly significantp = 1.2 × 10 −9
Moreover, surgical intervention occurred earlier in patients without osteolysis compared to patients with osteolysis (median 11.5 months compared to 72 months when duration since the primary prosthetic joint replacement was considered, and 2.5 versus 36 months since the last surgical intervention; the differences are highly significant with p = 1.2 × 10 −9 and p = 1.6 × 10 −13 , respectively).