Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors.

eNeuro · 2017 · PMC5458768 · PMID 28589175

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an unexpected trendno p-value reported

TyrC2 was then probed for a cation-π interaction with TC299423 and showed an unexpected trend, with F 3 Phe substitution resulting in a 30-fold increase in EC 50 .

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