Activated Natural Killer Cells Mediate the Suppressive Effect of Interleukin-4 on Tumor Development via STAT6 Activation in an Atopic Condition Melanoma Model.

In addition, the morphological features of the SK-MEL-28 cells showed a reduction in cell size and the rounding up of cells in the presence of IL-4 (25 ng/ml)–activated NK-92MI cells when compared with treatment with either IL-4 (25 ng/ml) or NK-92MI cells alone ( Figure 6 B ); however, NK cell and IL-4 inhibitory was abolished in the presence of TNF-α may be significant in the NK cell mediating IL-4 cancer cell growth inhibitory effect.

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