Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia.

In vivo Schmetzer’s group has shown that rats heavily diseased with promyelocyte-like leukemia and treated with DC leu -inducing Kits GM-CSF with Picibanil, prostaglandin 1 or 2 (PGE1 or PGE2) (patent-number 10 2014 014 993) showed a highly significant reduction of blasts, an increase of memory like T-cells, and a decrease of Treg after two Kit-applications in only 9 days, therefore, suggesting that as proof of principle, a DC leu induction in vivo could lead to T-cell activation resulting in a specific blast reduction.

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