highly significantp < 0.01
A comparison of the AD and AdjNL tissues was shown in Figure 1A , demonstrating that the six loci (HOXA11, CDKN2A EX2, EYA4, HOXA1, CDX2 and TWEFF2) showed highly significant hypermethylation in lung AD ( p < 0.01), particularly in the following loci: HOXA11 ( p = 6.86E-05), CDKN2A EX2 ( p = 1.85E-04), and EYA4 ( p = 8.41E-04).