WT CHCHD10 transfected cells showed a nonsignificant trend toward increased mitochondrial length compared to vector control transfected cells both at basal and carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) conditions ( Fig. 3i–k ).
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Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.
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