Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: <i>SMAD6</i> as an Important Contributor.

Front Physiol · 2017 · PMC5469151 · PMID 28659821

Europe PMC DOI

hedged sentence

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closest p · 1.0× alpha

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boldest claim

The sentences

borderline significancep = 0.05actually significant

Intriguingly, two genes ( NOTCH1 and NOS3 ) that previously had been associated with increased BAV risk in humans (Mohamed et al., 1797 ; Garg et al., 2005 ; McKellar et al., 2007 ; Foffa et al., 2013 ) and/or mice (Lee et al., 2000 ; Bosse et al., 2013 ) revealed borderline significance for protection from BAV/TAA ( p = 0.05 and p = 0.06, respectively).

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