Characterization of the MPS I-H knock-in mouse reveals increased femoral biomechanical integrity with compromised material strength and altered bone geometry.

Mol Genet Metab Rep · 2015 · PMC5471398 · PMID 28649535

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a decreasing trendno p-value reported

We further used Raman spectroscopy to evaluate the bone physiochemistry and demonstrated that female IDUA −/− mouse tibias have decreased mineral to matrix ratios and a decreasing trend in mineral to collagen ratios.

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