Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci.

Am J Hum Genet · 2017 · PMC5473725 · PMID 28528868

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hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 1.47 × 10 −172actually significant

A highly significant proportion (99.2%; sign test p = 1.47 × 10 −172 ) had the same direction of association across the two datasets ( Figure S3 ), and a large proportion (n = 337; 58.0%) satisfied the criteria for a pleiotropic association (p < 1.04 × 10 −6 and HEIDI p > 0.05) in the replication dataset as well.

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