Pilot study using 3D-longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy.

Integral-derived parameters were generated and described for the first time, and they were applied in heart failure patients eligible for CRT, producing the following primary findings: 1) automatic analysis of longitudinal strain curves provided new complementary data on LV mechanics by combining information on timing and LV regional performance; 2) the mean I L,peak and SDI L,peak of all 17 LV segments were higher in CRT responders than in non-responders; 3) While marginally significant in this study , SDI L,peak could have an independent value for predicting CRT response; and 4) combining a SDI L,peak value >1.037% s −1 and interventricular dyssynchrony appeared to be a promising multi-parametric approach for best predicting CRT response, and it was feasible and robust in patients with sufficient acoustic windows and a sinus rhythm.

also in 26,082 other papers