highly significantP =3.45 × 10 −7
These two highly significant SNPs (rs10842383 near LINC00477 , P =3.45 × 10 −7 and rs2680344 in HCN4 , P =4.34 × 10 −7 ( Supplementary Table 12 ) had large opposite effects on atrial fibrillation, while both decreased HRV.