APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

Neuroimage Clin · 2017 · PMC5476467 · PMID 28652970

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0.0520

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0.0520

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marginally significantp = 0.052so close (0.05 < p ≤ 0.1)

MR spectroscopy revealed a moderate and marginally significant (p = 0.052) difference of up to 10% of NAA/Cr ratio in wt mice when compared to tg mice of the same age (NAA/Cr ratio wt 0.97 ± 0.02, tg 0.89 ± 0.03). 3.3.

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