Metal Fluorides: Tools for Structural and Computational Analysis of Phosphoryl Transfer Enzymes.

Such analyses have identified the propensity of nucleotide analogs, particularly β,γ-iminoATP, β,γ-methyleneATP, and their GTP counterparts, to deliver NACs for phosphoryl transfer processes, which is now recognized in recent computational studies as capable of generating small but highly significant conformational changes in kinases and GTPases [ 44 , 108 ].

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