Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.

For example in CEU, the largest iHS score was 4.85 and highly significant, and was elevated across most of BCAS3 ( Fig 2B CEU, spanning introns 1–18 and various LD-blocks, Fig 2C ), which matched the approximate trends in CAD log odds giving rise to a highly significant positive correlation ( Fig 2A CEU).

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