Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest).

The 395 genes with reduced expression in eWAT of Mest pKO mice showed highly significant associations with immune system processes (Padjusted <10 −10 ) including defense, immune, inflammatory and stress responses whereas genes with increased expression in eWAT of Mest pKO mice (n = 301) showed enrichment for single-organism metabolic processes (Padjusted<10 −3 ) including oxidation-reduction, organic acid metabolism; and, fatty acid, acyl-CoA, thioester and monocarboxylic acid metabolism ( Fig 8B ).

also in 132,142 other papers