Cerebrospinal Fluid Total Tau is Increased in Normal Pressure Hydrocephalus Patients who Undergo Successful Lumbar Drain Trials.

Results CSF total tau was elevated, on average, in pre- and post-ELD samples from patients who failed to improve clinically during the ELD trial, but the findings were marginally significant after correction for multiple comparisons.

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There is some overlap between CSF total tau between these two groups and only marginal significance when assessed in the context of multiple comparisons, and so because of the small sample size of this study, it is not currently possible to assess the generalizability of these findings.

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