It has been proposed that cilengitide’s poor pharmacokinetics has ultimately led to its development being discontinued [ 70 , 78 ] although the observation that the pan-αv antagonist GLPG0187 was not effective as a monotherapy when delivered by continuous infusion suggests other factors, such as combination of integrins targeted, may be significant [ 79 ].
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The sentences
Members of the RGD-binding subfamily are highly significant in angiogenesis [ 17 ] and thrombosis, and have been considered some of the most important integrin targets for drug discovery.