Barely Significant
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The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability.

PLoS Genet · 2017 · PMC5484544 · PMID 28604780

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highly significantno p-value reported
The amino acid composition of the growth medium can affect yeast CLS [ 51 , 52 ], with methionine availability having a highly significant impact [ 53 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.