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Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance.

Sci Rep · 2017 · PMC5484693 · PMID 28652624

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a decreasing trendno p-value reported
TSAT also showed a decreasing trend with the progression of CKD stage.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.