ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype.

Using a chromatin immunoprecipitation (ChIP) protocol adopted to human-AT [42] , a highly significant correlation between BMI and E2F1 binding to the ASK1 promoter could be observed in both Om and Sc fat, though the effect of BMI was more robust for Om (Om: r = 0.920, p < 0.001; Sc: r = 0.650, p = 0.009, Figure 2 A).

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