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Evolution of three Nobel Prize themes and a Nobel snub theme in chemistry: a bibliometric study with focus on international collaboration.

Scientometrics · 2017 · PMC5486908 · PMID 28725094

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a decreasing trendno p-value reported
From T4—the period in which the Nobel Prize was awarded to the Ribozyme theme—to T6, a decreasing trend is observed for IPR.

also in 47,180 other papers

an increasing trendno p-value reported
The international collaboration rate shows an increasing trend for each theme.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.