Alternatively, by removal of sialyl residues from sialylated molecules on the cell surface, microbial NAs/sialidases may promote an excessive inflammatory response; desialylation of dendritic cells resulted in a highly significant proinflammatory cytokine response increase upon subsequent exposure to lipopolysaccharide (LPS) in vitro , while instillation of NA into murine lungs markedly exacerbated LPS-induced lung injury ( 32 , 41 ).
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Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited.
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