A space-time permutation scan statistic for disease outbreak detection.

PLoS Med · 2005 · PMC548793 · PMID 15719066

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highly significantno p-value reported

When we first tried the new method in New York City, a number of highly significant outbreak signals were generated that were artifacts of previously unrecognized missing or incomplete data from one or more hospitals.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.