HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.

However, repeat siRNA knockdown of CUL5 or HECTD3 caused robust, repeatable, and statistically highly significant (p < 0.0001 in paired t test) stabilization of eYFP-CRAF fluorescence at levels comparable to that obtained with repeat siRNA knockdown of UBE1 ( Figure 2 B).

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