Unbiased Protein Association Study on the Public Human Proteome Reveals Biological Connections between Co-Occurring Protein Pairs.

To verify the fundamental validity of our approach, we mapped protein pairs with a high degree of association to existing biological knowledgebases. The majority of these pairs were found to indeed be biologically associated. Furthermore, when we compared the level of biological association for the original results with that of protein pairs from randomized associations, we found an extremely significant drop in matches with existing knowledge, lending further support to the validity of our approach. 2 Methodology The human MS data from the PRIDE database (downloaded in May 2015) was used in this study and analyzed in three major steps ( Figure 1 a): (i) reprocess step, (ii) associations step, and (iii) annotations step.

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