Dual role for p16 in the metastasis process of HPV positive head and neck cancers.

Mol Cancer · 2017 · PMC5492443 · PMID 28662664

Europe PMC DOI

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closest p

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highly significantno p-value reported

p16 stimulates lymphangiogenesis and nodal spread in HPV positive HNSCC These results still do not explain the occurrence of the similar distant relapse rates in HPV/p16 positive and negative HNSCC patients and certainly do not explain the highly significant association between HPV positivity and nodal involvement described in our and several other studies [ 5 , 6 , 10 , 16 ].

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