borderline significantp = 0.08
6 ). Three studies including 158 participants reported the changes in urine volume between ACEI/ARB and placebo or active control therapy [ 11 , 17 , 18 ], and found ACEI/ARB treatment was a borderline significant factor in delaying the decline in urine volume: MD 167 ml, 95% CI 21 ml to 357 ml; p = 0.08) (Additional file 2 : Figure S2).