Liver Metastasectomy and Systemic Therapy Improve Overall Survival Compared With Surgery Alone After Curative Liver Resection of Colorectal Metastases in a Developing Country (Costa Rica).

Both these trials were prematurely closed because of slow accrual; however, the pooled analysis of these trials showed a nonsignificant trend toward better OS in patients receiving adjuvant therapy. 4 , 11 On the other hand, the EORTC (European Organization for Research and Treatment of Cancer) 40983 trial did not find any survival benefit after a median follow-up of 8.5 years in patients treated with perioperative FOLFOX4 compared with

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