These integrated miRNA:mRNA analyses therefore report highly significant results drawn from autopsy tissue and set the stage for exploring specific downstream hypotheses; they also suggest that miRNAs are just one element contributing to the changes in gene expression found in AD since most of the variance of the affected genes – such EP300 and the miR200a targeted genes – remains unexplained at this time.
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Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.
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