JNK Pathway-Associated Phosphatase/DUSP22 Suppresses CD4⁺ T-Cell Activation and Th1/Th17-Cell Differentiation and Negatively Correlates with Clinical Activity in Inflammatory Bowel Disease.

At last, we also observed that the proliferation and activation of CD4 + T cells by JKAP upregulation in IBD patients presented almost like that in HCs, which might result from that JKAP overexpression might greatly suppress the proliferation and activation of CD4 + T cells independently through multiple signaling pathways such as MAPK, TCR, and IL-6/STAT3, and its influence was extremely significant on CD4 + T cells, which needed to be further verified with larger samples and deeper experiments.

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