Analysis of the averaged H3K4me3 signal ±500 bp around 80 DSBs revealed a highly significant reduction of this mark after DSB induction compared with nondamage conditions or at 80 non–AsiSI-associated locations, randomly chosen for comparison ( Fig. 2 D ).
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Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair.
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