The ATP-dependent chromatin remodeler Chd1 is recruited by transcription elongation factors and maintains H3K4me3/H3K36me3 domains at actively transcribed and spliced genes.

Although this shift was small, it was highly significant because first, we observed the same behavior in two independent ChIP-seq datasets and second, it was very consistent across all genes with good ChIP-seq signal, as indicated by the clear separation of the 95% confidence intervals around the ChIP-seq signal density profiles (Figure 2B ).

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